How is Hyperparathyroidism diagnosed?

Diagnosing Hyperparathyroidism

Hyperparathyroidism is a medical condition characterized by the overactivity of the parathyroid glands, which are responsible for regulating calcium levels in the body. This condition can lead to elevated levels of calcium in the blood, causing various symptoms and complications. Diagnosing hyperparathyroidism involves a combination of medical history assessment, physical examination, laboratory tests, and imaging studies.

Medical History and Physical Examination

During the initial evaluation, the healthcare provider will take a detailed medical history to understand the patient's symptoms, risk factors, and any relevant family history. They will inquire about symptoms such as fatigue, weakness, bone pain, kidney stones, and changes in mental health. Additionally, they will assess the patient's overall health and perform a physical examination to check for signs of hyperparathyroidism, such as bone tenderness or abdominal discomfort.

Laboratory Tests

Several laboratory tests are essential in diagnosing hyperparathyroidism:

• Calcium Levels: Blood calcium levels are measured to determine if they are elevated. High calcium levels are a key indicator of hyperparathyroidism.


• Parathyroid Hormone (PTH) Levels: PTH levels are measured to assess the activity of the parathyroid glands. Elevated PTH levels, along with high calcium levels, suggest hyperparathyroidism.


• Phosphorus Levels: Phosphorus levels are checked as they can be affected by hyperparathyroidism. In this condition, phosphorus levels are often low.


• Vitamin D Levels: Vitamin D plays a role in calcium regulation, so its levels are measured to evaluate its impact on hyperparathyroidism.


• Kidney Function Tests: Hyperparathyroidism can affect kidney function, so tests like creatinine and estimated glomerular filtration rate (eGFR) are performed to assess kidney health.


• Bone Density Test: Dual-energy X-ray absorptiometry (DEXA) scan may be conducted to evaluate bone density and detect any signs of osteoporosis, which can be associated with hyperparathyroidism.


• Urinary Calcium Levels: A 24-hour urine collection may be requested to measure the amount of calcium excreted in the urine, which can help determine the cause of hypercalcemia.

Imaging Studies

Imaging studies are often used to locate the abnormal parathyroid gland(s) causing hyperparathyroidism:

• Ultrasound: Ultrasound imaging is a non-invasive technique that uses sound waves to create images of the neck. It can help identify enlarged or abnormal parathyroid glands.


• Sestamibi Scan: This nuclear medicine scan involves injecting a small amount of radioactive material into the bloodstream. It helps identify overactive parathyroid glands by highlighting their activity on the scan.


• Magnetic Resonance Imaging (MRI): In some cases, an MRI may be performed to obtain detailed images of the neck and locate abnormal parathyroid glands.


• Computed Tomography (CT) Scan: CT scans provide cross-sectional images of the neck and can help identify abnormal parathyroid glands.

Confirming the Diagnosis

Once the medical history, physical examination, laboratory tests, and imaging studies are evaluated, a diagnosis of hyperparathyroidism can be confirmed. The specific type of hyperparathyroidism (primary, secondary, or tertiary) can be determined based on the underlying cause and additional test results.

It is important to note that diagnosing hyperparathyroidism requires the expertise of a healthcare professional. If you suspect you may have hyperparathyroidism or are experiencing symptoms related to calcium imbalance, it is crucial to consult with a qualified medical practitioner for an accurate diagnosis and appropriate treatment.