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What is the prevalence of Lennox-Gastaut syndrome?

How many people does Lennox-Gastaut syndrome affect? Does it have the same prevalence in men and women? And in the different countries?

Prevalence of Lennox-Gastaut syndrome

The prevalence of Lennox-Gastaut syndrome (LGS) is estimated to be around 1 to 5 per 100,000 individuals. It is a rare and severe form of epilepsy that typically begins in childhood and continues into adulthood. LGS is characterized by multiple seizure types, intellectual disability, and developmental delays. The exact cause of LGS is often unknown, but it can be associated with brain malformations, genetic mutations, or brain injuries. Early diagnosis and appropriate management are crucial in improving the quality of life for individuals with LGS.



Lennox-Gastaut syndrome (LGS) is a rare and severe form of epilepsy that typically begins in childhood. It is characterized by multiple types of seizures, cognitive impairment, and abnormal electroencephalogram (EEG) patterns.


The prevalence of Lennox-Gastaut syndrome is estimated to be around 1 to 5 per 10,000 individuals, making it a relatively uncommon condition. It accounts for approximately 1-4% of childhood epilepsy cases.


LGS is more commonly diagnosed in children between the ages of 3 and 5, but it can also affect older children and adults. The exact cause of LGS is often unknown, although it can be associated with brain injuries, genetic mutations, or developmental disorders.


Managing LGS can be challenging as it often does not respond well to traditional anti-seizure medications. However, there are various treatment options available, including anti-epileptic drugs, ketogenic diet, and neurostimulation techniques, which aim to control seizures and improve quality of life.


Early diagnosis and intervention are crucial in managing LGS, as it can significantly impact a person's cognitive and physical development. Close collaboration between healthcare professionals, caregivers, and individuals with LGS is essential to provide comprehensive care and support.


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2 answers
Incidence is estimated at 1:1,000,000 inhabitants per year, and the estimated prevalence is 15/100,000. LGS represents 5-10% of epileptic patients, and 1-2% of all childhood epilepsies.

Posted May 19, 2017 by Brittney 2000

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My daughter Katie was born perfectly healthy and "normal". When she was 8 months old, she got sick and had her first seizure. Her first three seizures were within 13 hours and each lasted longer than a half hour. Almost 4 years later, we are still ba...
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LGS may usually be diagnosed at a younger age like 3-5, but my daughter was 10 and in 4th grade when she started having seizures. Her neurologist at DHMC was surprised when she was coming out of status epilepticus, after a couple days of IV therapy a...

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