What is the prevalence of McCune Albright?
How many people does McCune Albright affect? Does it have the same prevalence in men and women? And in the different countries?
McCune Albright is a rare genetic disorder characterized by a triad of symptoms: fibrous dysplasia of bone, café-au-lait skin pigmentation, and endocrine abnormalities. It affects multiple systems and can manifest differently in each individual. The prevalence of McCune Albright is estimated to be around 1 in 100,000 to 1 in 1,000,000 people. Due to its rarity, it is considered a rare disease. Early diagnosis and management are crucial for optimizing patient outcomes.
McCune-Albright syndrome is a rare genetic disorder that affects multiple systems in the body. It is characterized by the presence of abnormal bone growth, endocrine abnormalities, and skin pigmentation changes. The syndrome is caused by a mutation in the GNAS gene, which leads to the overactivation of certain signaling pathways.
Due to its rarity, the prevalence of McCune-Albright syndrome is not well-established. However, it is estimated to occur in approximately 1 in 100,000 to 1 in 1,000,000 individuals. The condition affects both males and females, and there is no known ethnic or geographic predisposition.
McCune-Albright syndrome can present at any age, but it is often diagnosed in childhood. The severity and specific symptoms can vary widely among affected individuals. Common features include bone deformities, such as uneven growth or fractures, hormonal imbalances leading to early puberty or other endocrine disorders, and skin abnormalities like café-au-lait spots.
Diagnosis of McCune-Albright syndrome involves a combination of clinical evaluation, imaging studies, and genetic testing. Treatment is focused on managing the specific symptoms and may involve a multidisciplinary approach with specialists in orthopedics, endocrinology, and dermatology.
