The symptoms differ considerably between some individuals and others. Can be very varied, from swallowing problems, vision and stomach, joint and heart, without having a mental disability between medium and severe.
Of all the range possible, because they do not always have all, to me, that can lead to a greater negative impact on those affected are, in decreasing order, due to their frequency and severity: serious mental disabilities, stomach problems, heart, joints, and skeletal, vision.