Research constantly shows that exercise is beneficial to health and it is no different in systemic scleroderma. However, patients are often limited in what they can do, especially when scleroderma affects the lungs, which is very common. Fatigue can also be a limiting factor. Basically, patients with systemic scleroderma should do as much moderate exercise as they are able to do, but it will vary widely depending on the symptoms that patients are dealing with.