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What is the prevalence of Scleroderma?

How many people does Scleroderma affect? Does it have the same prevalence in men and women? And in the different countries?

Prevalence of Scleroderma

Scleroderma is a rare autoimmune disease characterized by abnormal growth of connective tissue. It affects approximately 75,000 to 100,000 people in the United States, with a higher prevalence among women. The exact cause is unknown, but it is believed to involve genetic and environmental factors. Scleroderma can vary in severity and affect different organs, leading to symptoms such as skin thickening, joint pain, and internal organ damage. Early diagnosis and treatment are crucial for managing the disease and improving quality of life for those affected.

Scleroderma is a rare autoimmune disease characterized by the hardening and tightening of the skin and connective tissues. It is estimated that the prevalence of scleroderma varies worldwide, with approximately 240 cases per million people. However, it is important to note that these numbers may vary depending on the population studied and the diagnostic criteria used.


Systemic sclerosis, the most severe form of scleroderma, affects approximately 75,000 to 100,000 individuals in the United States. It is more common in women than men, with a female-to-male ratio of about 3:1. The disease typically manifests between the ages of 30 and 50, although it can occur at any age.


Localized scleroderma, a milder form of the disease, is estimated to affect about 2 to 20 per 100,000 individuals. It often begins in childhood or adolescence and is more common in females.


While scleroderma is considered a rare disease, it can have a significant impact on the quality of life for those affected. Early diagnosis and appropriate treatment are crucial in managing the symptoms and preventing complications.


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2 answers
Scleroderma is a rare chronic autoimmune disease that affects mostly women between the ages 30-50 years old. It is more common in black women for some reason and Indian women.

Posted Mar 30, 2018 by Amy 2600

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In 1996 I was diagnosed with Systemic Diffuse Scleroderma. I had never heard of it, couldn't spell or pronounce it. Fast forward 20 years and I can say that Scleroderma has been a blessing in my life, not a curse. In 1996 I almost immediately was ho...
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I was officaily diagnosed in 2013 at age 52. My dermatoligist ran blood tests becaause I was complaining of the apperance of several red spots (telangiectasias) and Raynauds symptoms. She came back with the news that I have CREST syndrome, a conne...
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Hello, my name is Claire. I was diagnosed with extensive Localized Cutaneous Scleroderma in December of 2012 at the age of 4.5 years.    
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It took me several years before I got  diagnosed. I even had one doctor tell me that it was all in my head. For years I always had an excuse for why feeling the way that I was, stress or taking on to much. Then finally I saw the correct doctor and g...
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I was dianosed in the late 1950s with En Coup De Sabre Localized Scleroderma when I was around 5-7 years old.

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