Absolutely yes! People can work; however, it is important that any repetitive work might cause damage or be difficult for those with arthritis, Raynaud's, or rheumatism in their hands. Computer work is easy for some and some might even work outdoors in milder climates. Cold and wet weather might be difficult for those with Raynaud's. Some who have COPD or breathing issues might have difficulty with rigorous activity/work. I've had this label since 2000 and yet, I was able to teach, move about, and use a computer. However, many have Scleroderma features that prevent them from moving without pain or difficulty. Now that I'm retired, I'm able to move but have pain in my knees, shoulder, and have difficulty getting out of bed in episodes. Fortunately, not often. I am fortunate to still be somewhat active in my 70's. I do not know the percentage of those as active as I am but I believe, I am fortunate to not be severely impacted (so far. by Scleroderma.