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Vitiligo
> Publications
Publications of Vitiligo
Preferential secretion of inducible HSP70 by vitiligo melanocytes under stress
http://onlinelibrary.wiley.com/doi/10.1111/pcmr.12208/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=
by Clínicas
Healthcare professional
Mutant HSP70 Reverses Autoimmune Depigmentation in Vitiligo
http://stm.sciencemag.org/node/186571.full
by Clínicas
Healthcare professional
Variant of TYR and Autoimmunity Susceptibility Loci in Generalized Vitiligo
http://www.nejm.org/doi/full/10.1056/nejmoa0908547
by Clínicas
Healthcare professional
We previously reported a genome-wide association study (GWAS) identifying 14 susceptibility loci for generalized vitiligo. We report here a second GWAS (450 individuals with vitiligo (cases) and 3,182 controls), an independent replication study (1,440 cases and 1,316 controls) and a meta-analysis (3,187 cases and 6,723 controls) identifying 13 additional vitiligo-associated loci. These include
OCA2-HERC2
(combined
P
= 3.80 × 10
−8
),
MC1R
(
P
= 1.82 × 10
−13
), a region near
TYR
(
P
= 1.57 × 10
−13
),
IFIH1
(
P
= 4.91 × 10
−15
),
CD80
(
P
= 3.78 × 10
−10
),
CLNK
(
P
= 1.56 × 10
−8
),
BACH2
(
P
= 2.53 × 10
−8
),
SLA
(
P
= 1.58 × 10
−8
),
CASP7
(
P
= 3.56 × 10
−8
),
CD44
(
P
= 1.78 × 10
−9
),
IKZF4
(
P
= 2.75 × 10
−14
),
SH2B3
(
P
= 3.54 × 10
−18
) and
TOB2
(
P
= 6.81 × 10
−10
). Most vitiligo susceptibility loci encode immunoregulatory proteins or melanocyte components that likely mediate immune targeting and the relationships among vitiligo, melanoma, and eye, skin and hair coloration.
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Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo
http://www.nature.com/ng/journal/v44/n6/abs/ng.2272.html
by Clínicas
Healthcare professional
Reduced skin homing by functional Treg in vitiligo
http://onlinelibrary.wiley.com/doi/10.1111/j.1755-148X.2010.00688.x/full
by Clínicas
Healthcare professional
Genome-Wide Analysis Identifies a Quantitative Trait Locus in the MHC Class II Region Associated with Generalized Vitiligo Age of Onset
http://www.jidonline.org/article/S0022-202X(15)35307-0/abstract
by Clínicas
Healthcare professional