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What is the prevalence of Adams-Oliver syndrome?
How many people does Adams-Oliver syndrome affect? Does it have the same prevalence in men and women? And in the different countries?
It’s the same for men and women. 50% out of 2 kids with carrier.
Posted Aug 16, 2019 by Amanda 3000
The prevalence is estimated to be 1 in 225,000 births (but this is only based on one study so may be higher).
Regarding inheritance, there are some important points to note:
- It doesn't matter how many children (or siblings) you have. The 50% (or 1 in 2) risk refers to the risk of every pregnancy.
- The risk is calculated from the different possible combinations of egg and sperm, which is completely random. So if you carry a genetic variant in your family, each pregnancy will have the same risk (irrespective of how many affected children you already have).
- It also depends on which gene is affected. Not all genes have a 50% risk - some have a 25% (or 1 in 4) risk. Please see my post in 'Is Adams-Oliver syndrome hereditary' for more information: https://www.diseasemaps.org/adams-oliver-syndrome/top-questions/hereditary/
Dr Laura Southgate
(Genetics Researcher)
Regarding inheritance, there are some important points to note:
- It doesn't matter how many children (or siblings) you have. The 50% (or 1 in 2) risk refers to the risk of every pregnancy.
- The risk is calculated from the different possible combinations of egg and sperm, which is completely random. So if you carry a genetic variant in your family, each pregnancy will have the same risk (irrespective of how many affected children you already have).
- It also depends on which gene is affected. Not all genes have a 50% risk - some have a 25% (or 1 in 4) risk. Please see my post in 'Is Adams-Oliver syndrome hereditary' for more information: https://www.diseasemaps.org/adams-oliver-syndrome/top-questions/hereditary/
Dr Laura Southgate
(Genetics Researcher)
Posted Feb 6, 2020 by Laura 650
It's very very rare. Please join Disease Maps so we can collate and share helpful information with researchers to advance knowledge
Posted Jan 14, 2023 by Trudy, Steph's mum 2650
