Treatment for ACC and other cancers are always changing, and the life expectancy changes with those improvements.
Each ACC case is unique. The location, stage, histology, treatment protocols followed and individual biology can all factor into disease progression and longevity. There are cases of complete control of primary tumor sites with no metastases lasting many years. There are also cases of rapid progression and aggressive metastatic behavior. In a study of 160 ACC patients followed from 1977 through 1996, disease specific survival was 89% at 5 years, but less than 40% at 15 years. Because ACC is most commonly found to be a slow growing cancer, most people who are initially diagnosed have many years of life, even in cases of more advanced tumor involvement. Of course, each case is different and there are so many factors that can affect the prognosis that each case can vary greatly. In medical studies that track particular groups of ACC patients, most studies do not go beyond 10 years, but some have tracked patients for 20 years or more. In many of the longer-term studies, 60% to 70% of the study groups are still alive 10 years after initial diagnosis, a 15-year survival rate of around 40% and some patients have been reported to live over 40 years after initial diagnosis. With the advent of newer treatment protocols, earlier diagnosis, scientific research, complementary medicine, better communications provided by the INTERNET, and more sophisticated techniques and equipment, it is expected that ACC cancer patients will continue to experience longer life spans with better quality of life than before. The two issues that appear to affect longevity are metastasis and infiltration.