How do I know if I have Alternating Hemiplegia Of Childhood?

Alternating Hemiplegia of Childhood (AHC) is a rare neurological disorder that typically begins in infancy or early childhood. It is characterized by recurrent episodes of temporary paralysis, known as hemiplegia, which affects one side of the body. These episodes can last for minutes, hours, or even days. AHC is a genetic disorder caused by mutations in specific genes, although the exact cause is not fully understood.

If you suspect that you or your child may have AHC, it is important to consult with a healthcare professional for a proper diagnosis. A thorough medical evaluation is necessary to rule out other conditions that may present similar symptoms. A neurologist or a specialist in genetic disorders would typically be involved in the diagnostic process.

Some of the key signs and symptoms of AHC include:

• Episodic hemiplegia: Recurrent episodes of temporary paralysis affecting one side of the body. These episodes can be triggered by various factors such as stress, excitement, physical activity, or changes in temperature.


• Eye movement abnormalities: Individuals with AHC may experience abnormal eye movements, such as nystagmus (involuntary eye movements) or strabismus (crossed or misaligned eyes).


• Developmental delays: Children with AHC may experience delays in reaching developmental milestones, such as sitting, crawling, walking, or speaking.


• Seizures: Some individuals with AHC may also have seizures, which can vary in type and severity.


• Cognitive and behavioral issues: AHC can be associated with intellectual disability, learning difficulties, attention deficit hyperactivity disorder (ADHD), and other behavioral problems.

It is important to note that the symptoms of AHC can vary widely between individuals. Not all individuals with AHC will experience all of the symptoms mentioned above, and the severity of symptoms can also differ.

Diagnosing AHC typically involves a combination of clinical evaluation, genetic testing, and ruling out other possible causes. Genetic testing can help identify mutations in the ATP1A3 gene, which is associated with AHC in the majority of cases.

Early diagnosis of AHC is crucial for appropriate management and treatment. While there is currently no cure for AHC, various interventions can help manage symptoms and improve quality of life. Treatment may involve medications to control seizures, physical and occupational therapy to address motor difficulties, and supportive care to manage other associated symptoms.

If you suspect that you or your child may have AHC, it is important to seek medical advice and guidance from healthcare professionals who specialize in neurological disorders.