Langerhans Cell Histiocytosis synonyms

Langerhans Cell Histiocytosis Synonyms:

Langerhans Cell Histiocytosis (LCH) is a rare disorder characterized by the abnormal proliferation of Langerhans cells, a type of immune cell. This condition can affect various organs and tissues throughout the body. While it is commonly referred to as Langerhans Cell Histiocytosis, there are several other terms used to describe this condition:

• Histiocytosis X: This term was previously used to describe a group of disorders that included LCH. However, it is no longer widely used as it does not accurately reflect the underlying cellular abnormalities.


• Eosinophilic Granuloma: This term is sometimes used to describe a localized form of LCH, typically involving a single bone or a limited number of bones. It is characterized by the presence of eosinophils, a type of white blood cell, within the granulomas.


• Hand-Schuller-Christian Disease: This term is used to describe a more disseminated form of LCH that primarily affects children. It is characterized by the triad of skull lesions, diabetes insipidus (a condition that affects water balance), and exophthalmos (protrusion of the eyes).


• Letterer-Siwe Disease: This term is used to describe a severe and rapidly progressive form of LCH that primarily affects infants. It is characterized by widespread involvement of multiple organs, including the skin, liver, spleen, and bone marrow.

It is important to note that while these terms may be used interchangeably, they all refer to different manifestations of Langerhans Cell Histiocytosis. The specific terminology used may depend on the clinical presentation, age of the patient, and extent of organ involvement.