Lipedema can cause situational depression. The most difficult thing to deal with initially is how it affects your appearance. People assume you are lazy and eat poorly. It’s difficult to find clothes that fit. Doctors and people may fat shame you. As it progresses it also causes significant pain and limits functionality including the ability to walk. How it affects your mood really depends upon your outlook. That said, even though I am a positive person in general, I would try to hid my legs and I was constantly aware of people staring at my thighs.