There are many known causes of both types of Panhypopituitarism. In regards to Acquired Panhypopituitarism, it is usually caused by a pituitary tumor or similar trauma to the area such as a serious infection, disease or radiation. Also, in rarer cases, obesity and starvation can cause Panhypopituitarism as well. The other side to this, though is Congenital Panhypopituitarism which stems from a genetic cause. Often times, it is triggered due to unexpected, yet catastrophic genetic mutations in the womb. Also, SOD/ONH is known to cause Panhypopituitarism in patients as well. Thus, being born with Panhypopituitarism is caused either by heredity or by fluke genetic mishaps while in utero.