If you experience severe fatigue, even after getting a good night's rest, or if you constantly have insomnia that should be one warning sign. Also, if you have painful unexplained headaches that do not go away for days, they could be caused by a pituitary tumor. Of course, join pain and irritability are other more vague symptoms to look out for. Also, unexplained weight gain/loss, nausea, dizziness, and sensitivity to cold (poor temperature regulation) are all warning signs. and then, if you experience a low sex drive or are infertile or do not experience menstrual cycles etc, those are some more serious symptoms that should definitely be discussed with your PCP and/or an Endocrinologist or Gynecologist. If you have more than one of these symptoms it is urgent that you see a doctor as soon as possible as Panhypopituitarism is a very serious disease that is life-threatening in certain emergency circumstances and you could be at risk of unknown adrenal crisis if left undiagnosed.