Relapsing polychondritis can cause depression. The constant pain, frustration of dealing with doctors not knowledgeable in the condition, the way it can affect relationships, not being able to exercise or work. The change in body size due to medications, the loss of hair due to medications. A number of factors contribute to depression. Finding a psychologist can help with depression and also having a support group who can support you and understand how you are feeling helps. Having family and friends who understand your condition and support you helps. Finding activities or hobbies helps also.