What is the history of Takayasus Arteritis?
When was Takayasus Arteritis discovered? What is the story of this discovery? Was it coincidence or not?
Takayasu's Arteritis, also known as Takayasu Arteritis (TA), is a rare chronic inflammatory disease that primarily affects the large blood vessels, particularly the aorta and its branches. It was first described by Dr. Mikito Takayasu, a Japanese ophthalmologist, in 1908. Dr. Takayasu initially observed the disease in a young woman who presented with retinal changes and weak pulses in her upper extremities.
The history of Takayasu's Arteritis can be traced back to the early 20th century. After Dr. Takayasu's initial observation, the disease gained recognition and was named "pulseless disease" due to the characteristic weak or absent pulses in affected arteries. However, it was not until the 1940s that the disease was more comprehensively studied and understood.
During the mid-20th century, advancements in medical imaging techniques allowed for better diagnosis and understanding of Takayasu's Arteritis. Angiography, a procedure that visualizes blood vessels using contrast dye, became a crucial tool in identifying the characteristic arterial lesions associated with the disease. This led to the recognition of the disease as a distinct entity and its subsequent renaming to "Takayasu's Arteritis" in honor of its discoverer.
Research on the etiology and pathogenesis of Takayasu's Arteritis has been ongoing. It is believed to be an autoimmune disease, where the body's immune system mistakenly attacks the arterial walls, leading to inflammation and subsequent narrowing or occlusion of the affected vessels. The exact cause of the disease remains unknown, but genetic and environmental factors are thought to play a role.
Takayasu's Arteritis predominantly affects young women, particularly those of Asian descent. However, cases have been reported worldwide, indicating its global prevalence. The disease typically presents in individuals under the age of 40, with symptoms such as fatigue, muscle pain, fever, and diminished pulses in the extremities.
Over the years, treatment options for Takayasu's Arteritis have evolved. Initially, corticosteroids were the mainstay of therapy, aimed at reducing inflammation. However, as our understanding of the disease has deepened, additional immunosuppressive agents, such as methotrexate and biologic agents, have been introduced to manage the disease more effectively.
Today, early diagnosis and prompt treatment are crucial in managing Takayasu's Arteritis and preventing complications. Regular monitoring of disease activity, blood pressure control, and lifestyle modifications are also important aspects of long-term management. Despite the challenges posed by this chronic condition, advancements in medical research continue to improve our understanding of Takayasu's Arteritis and enhance patient outcomes.
Posted May 31, 2017 by Salosh 3601
Posted Sep 10, 2017 by Vandanaa Suran 1700
described in 1908 by Japanese ophthalmologist Mikito Takayasu at the Annual Meeting of the Japan Ophthalmology Society. Takayasu described a peculiar "wreathlike" appearance of the blood vessels in the back of the eye (retina). Two Japanese physicians at the same meeting (Drs. Onishi and Kagoshima) reported similar eye findings in individuals whose wrist pulses were absent.
It is now known that the blood vessel malformations that occur in the retina are an angiogenic response to the arterial narrowings in the neck and that the absence of pulses noted in some people occurs because of narrowings of the blood vessels to the arms. Takayasu described a peculiar "wreathlike" appearance of the blood vessels in the back of the eye (retina). Two Japanese physicians at the same meeting (Drs. Onishi and Kagoshima) reported similar eye findings in individuals whose wrist pulses were absent.
Posted Sep 11, 2017 by Taylor 2650
Posted Sep 2, 2017 by Angie Cortéz 3550
