A study suggests mutations in a gene called SLITKR1 may play a role in the development of trichotillomania in some families. The mental disorder causes people to compulsively pull their hair out, resulting in noticeable hair losshair loss and bald spots.
Researcher Stephan Züchner, MD, of the Duke Center for Human Genetics, says genetic mutations only account for a small fraction of trichotillomania cases, but the findings may help lead to a better understanding of the unusual disorder.
In the study, published in Molecular Psychiatry, researchers studied 44 families in which one or more members had trichotillomania.
They focused on the gene SLITRK1 because a previous study had linked it to Tourette's syndrome, a related impulse-control disorder.
The study showed two mutations in this gene were found among family members with trichotillamania, but not in unaffected family members.