The only treatment for Addison's is to replace the life-sustaining hormone (cortisol) that your body can no longer produce with glucocorticoid steroids. Hydrocortisone most closely matches cortisol but in some cases of rapid matabolism, longer acting steroids like predinosolone or or prednisone may be more effective. In cases of malabsorption caused by other conditions, such as gastroparesis, hydrocortisone injections may be substituted. In cases of failure of the adrenals (as opposed to failure of the pituitary) the hormone aldosterone must also be replaced with the mineralcorticoid steroid Fludrocortisone. Many are afraid of life-long steroid therapy, but the many negative effects often associated with steroids do not apply to this disease because you are only replacing what your body no longer makes, not taking large amounts in addition to naturally produced steroids.