Citing from Mayo clinic website:
"Ankylosing spondylitis has no known specific cause, though genetic factors seem to be involved. In particular, people who have a gene called HLA-B27 are at greatly increased risk of developing ankylosing spondylitis. However, only some people with the gene develop the condition.
Risk factors
Your sex. Men are more likely to develop ankylosing spondylitis than are women.
Your age. Onset generally occurs in late adolescence or early adulthood.
Your heredity. Most people who have ankylosing spondylitis have the HLA-B27 gene. But many people who have this gene never develop ankylosing spondylitis."
Research continues to try and breakthru what the actually causes are but it is known that it is mainly genetically acquired and hereditery by HLA-B27 gene. Not everyone with the gene with end up becoming active with the disease though. Environmental factors are also thought to be a factor and the immune system is a biggie. They believe if stress or trauma even perhaps a bacterial infection of some sort occurs it activates the disease and causes the inflammation and when this occurs the bodies immune system never really recovers. It is active. Not everyone person is the same either. What one person may have may be totally different from the next. So everyone can experience different signs and symptoms and progression.
I dont know that there is a clear definitive answer here though there appears to be a genetic relationship to some interlukeins and the hla-b27 genetic marker.
There is no recognised cause. It is believed that the immune system responds to something and goes into over drive. It then never turns off. One of the suspected caused is bacteria in the bowel.
Although there are no known causes to Spondylitis, and injury and environment with the right genetic make up is the general answer. Since 2015 gut bacteria by certain foods and infections have been studied with promising results.
From all the data I've read and talked about with my rheumy, there is no known reason for the cause of AS; however the HBL-A27 gene is associated with the disease...you can have the gene but not get AS and vice verse...interesting to say the least.
On the day of today there is not evidence yet of the causes. Although scientists seems to agree it could be a combination of factors as genetics and environment.
It is also discussed that it can be triggered by an infection or by a macrobiotic issue.
Hello. My name is Guyla Galindo. I’m 62 years old and live in Washington state. I have ankylosing spondylitis (AS), lupus, fibromyalgia, chronic ptsd/depression, and polycystic kidney disease. I remember http://thefacesofankylosingspondylit...
11/01/2015
After a trip to the Emergency Room with severe pain and limited mobility on New Year’s morning of 2013, a visit to my primary care physician and a referral to a bone specialist resulting in a positive test for the HLA-B27 gene marker an...
Starting with oldest to newest diagnosed.
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