It really depends on how severe they symptoms are, and how much you are able to push yourself. I am 90% functional after 5 years of treatment, but I still have my ups and downs. And I was not as sick initially as some people, because I was only undiagnosed for a year and did not have any serious coinfections. However, I still cannot work full time reliably.
As far as the type of work people with Lyme can do, it also depends on your symptoms. I know a lot of people that find jobs working online or from home, but those jobs are not always the easiest to find or the most lucrative. What I would recommend overall is to work a job where you can either make your own hours or telework on days that you cannot make it in. If that is not possible, and you feel that you can work, find a job that where your supervisor is supportive and readily willing to accommodate you. Employers legally are required to give employees reasonable accommodation per the Americans with Disabilities Act. However, some employers will still find ways around that and discriminate employees with invisible illnesses like Lyme Disease.