The normal life expectancy for those living with AS is that of normal people without the disease unless a severe complication arises. Complications such as fusion can lead to bamboo spine or hunchback or of the SI joints as well and also extra bone growth that could lead to surgery. With AS in later progression the heart, lungs, And eyes can be affected leading to infection in the organs causing hospitalization and at times strong antibiotics and you can also get secondary infections from those infections leading to pneumonia, pleurisy, pericarditis, costochondritis, uvitis if the eye and if left untreated can lead to infection in brain, but these are usually caught but can happen and be life threatening. They believe AS is caused by a variety of factors such as generics, environment, and immune system. Also if the immune system TNF marker which is what leads to inflammation is to much the body will inflame and cause severe pain and swelling do the joints. Thjs can cause alot of discomfort and difficulty with mobility as well. Research continues to try and find out further information and is ongoing with many groups which leads to hope amongst the AS community. Although there is no cure at this time we are hoping one day they will find one. As they know HLA-B27 marker is main gene related to AS as well as some environmental fsctors, and our weakened immune systems. Alot of our infections are stemed from the gut so Probiotics are essential if able to take them to help restore good bacteria as well as some vitamins and supplements but talk to your dr about them before starting them. We continue to have hope as research continues that a breakthru will occur.