What is Parry-Romberg syndrome / Progressive hemifacial atrophy

Parry-Romberg syndrome, also known as Progressive Hemifacial Atrophy, is a rare neurological disorder characterized by the progressive wasting away (atrophy) of the tissues on one side of the face. The condition typically begins in childhood or adolescence and worsens over time.

Symptoms of Parry-Romberg syndrome include facial asymmetry, loss of fat and muscle tissue, and skin changes such as pigmentation alterations and hair loss. In some cases, it may also affect the underlying bone structure, leading to dental and jaw abnormalities. The severity and progression of symptoms can vary widely among individuals.

The cause of Parry-Romberg syndrome is still unknown, but it is believed to involve an autoimmune or inflammatory process affecting the blood vessels that supply the face. Some cases have been associated with a history of trauma or infection, but no definitive triggers have been identified.

Treatment for Parry-Romberg syndrome focuses on managing the symptoms and may include medications to reduce inflammation, surgical interventions to correct facial deformities, and cosmetic procedures to improve appearance. Physical therapy and psychological support can also be beneficial for individuals affected by this condition.

While Parry-Romberg syndrome is a challenging condition to manage, ongoing research aims to improve our understanding of its underlying mechanisms and develop more effective treatments.