What are the best treatments for Phenylketonuria?

People who follow the prescribed dietary treatment from birth may have no symptoms. Their PKU would be detectable only by a blood test. People must adhere to a special diet low in Phe for optimal brain development. Since Phe is necessary for the synthesis of many proteins, it is required for appropriate growth, but levels must be strictly controlled.

To begin with, the first thing proposed is to balance the amounts of phenylalanine a person receives throughout his daily meals. Food is separated in food a person can eat freely, food that the person is forbidden to eat and food that is in a gray area and maybe sometimes can be consumed carefully. For example, meat is off the table but most vegetables and fruits are edible (with some exceptions that belong to the gray area). Apart from that, in order for the person to be able to take all the nutrients needed, there is a formula that is measured and received (few times a day). Lately, there has been a medicine called Kuvan, that is in the proposed treatment for Phenylketonuria. It aims in lowering the phe levels in one's blood, in order to have a more "relaxed" diet.

All of the above are valid for a person's lifespan. Phenylketonuria does not "go away" with the treatments that exist so far.

I believe it depends on how sensitive you are to protien. I have a case that I am highly sensitive and can only have 1.5 grams of protien per day. Formula is a must to keep levels low but it really benefits one to have an excellent idea of sensitivity for treatment

Formula and a low protein diet is ideal
There is also treatment with Palynziq and Kuvan
Gene Therapy is also a new treatment for PKU in clinical trials